Somite.ai is leveraging big data and AI to introduce novel cell replacement therapiesExplore more
Somite.ai is on a mission to transform the lives of millions of people by leveraging AI to produce human tissue for cell-based therapies.
We’re developing a digital twin of the embryo, i.e. a computational model that simulates the real embryo's development and behavior to guide decision-making.
Constructed from data-rich sources (scRNA-Seq, scATAC-seq, gene expression databases, etc.) our digital twin allows us to leverage Artificial Intelligence to rapidly identify novel protocols for generating new cell types, discover new regulators of cell differentiation, and carry out rapid protocol optimization cycles.Read white paper
Cell replacement therapy:
Cell therapy replaces missing, damaged, or diseased cells to treat medical conditions. Recent advances in stem cell research have unlocked new methods for the production of multiple human cell types. However, production of many cell types remains elusive, and existing protocols vary in efficiency, scalability, and robustness.
Cells of the musculoskeletal system derive from transient embryonic structures called somites. Somite.ai is the only company proficient in producing somite-derived cells efficiently. These mainly include muscle, brown adipose, cartilage, bone, tendon and dermis.
Somite's proprietary digital twin allows us to surface actionable insights and quickly iterate on protocols. A good example comes from human satellite and brown adipose cells, where applying computation analysis and AI allowed us to identify signatures of ligand-mediated signaling with different pathways from those used in an established protocol. A resulting optimized protocol using these predictions helped us increase purity of the cultures from 25% to over 50% without requiring cell sorting procedures.
Why are somite
derived cells important?
There are a wide range of conditions that involve a loss of somite-derived cell populations. These could all be treated by cell replacement therapy using somite-derived cells.
Metabolic diseases (e.g. Diabetes, Obesity, MAFLD - including NASH)
Duchenne muscular dystrophy (DMD), incontinence and muscle injuries
Joints and cartilage injuries
Tendons and chondrocytes
Connective tissue syndromes (e.g. Hypermobility, EDS)
We are the only company that can effectively differentiate somite-derived cells and has the ability to leverage data and AI to optimize production protocols.
Our team has authored the seminal patents in the space and we have signed a binding letter to exclusively license the founding patent from the French Association for Muscular Dystrophies (AFM) and INSERM.
Meet the team
Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophyChal et al., Nature Biotech, 2015 PUBLICATION
Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitroChal et al., Nature Protocols, 2016 PUBLICATION
Reconstructing human brown fat developmental trajectory in vitroRao et al., Dev Cell, 2023 PUBLICATION
The dynamics of gene expression in vertebrate embryogenesis at single-cell resolutionBriggs et al., Science, 2018 PUBLICATION
Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryoWagner et al., Science, 2018 PUBLICATION
Reprogramming limb progenitorsAtsuta et al. Dev Cell, 2023
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